Vendredi 1er juillet – Étape 60 de Nagyigmand à Tata – 24 kms
Hongrie Jour après jour
Vendredi 1er juillet – Étape 60 de Nagyigmand à Tata – 24 kms
Hongrie Jour après jour

Vendredi 1er juillet – Étape 60 de Nagyigmand à Tata – 24 kms

Nous acceptera ou nous acceptera pas ?
Le lac de Tata

Ce matin, réveil matinal à 4h30 pour un départ à 5h. Ce n’est pas parce que l’étape est aussi longue mais tout simplement, la météo annonçant encore des températures caniculaires, nous décidons donc de partir marcher à la fraîche.

Geneviève nous a fait de belles frayeurs ce matin. Même pas 100 mètres après avoir quitté notre logement, elle est tombée lourdement dans des escaliers du parc en voulant éviter des toiles d’araignées. Et là plus de peur que de mal.

Nous prenons donc enfin le chemin, d’abord sur quelques kilomètres de goudron, puis sur de beaux chemins forestiers pour la plupart du temps. Dommage que le sol soit souvent sablonneux, comme hier, car nous arriverons particulièrement sales à cause de cette poussière collant à notre transpiration.

Avant d’arriver à Mocsa, l’unique village de la journée, nous traverserons à nouveau l’autoroute M1 avec toutes ses nuisances sonores.

A l’entrée du village, à 8h30 ce matin, il faisait déjà 27 degrés et nous nous réjouissions, certes un peu trop vite, pour un bon café. Malheureusement, le corona a fait une victime de plus et ainsi le restaurant n’ouvrira plus ses portes.

Dès notre arrivée à Tata, vers 14h, nous nous dirigeons vers l’Office de tourisme pour trouver un hébergement pour ce soir. Évidemment, encore une fois, rien pour les pèlerins, mais tout pour les touristes.

Il en sera de même à l’église catholique ainsi qu’au temple protestant et à la synagogue.

Pas grave, nous finirons bien par nous habituer à ces réponses négatives. D’ailleurs la météo n’annonçant pas d’orage ce soir, celà pourrait même être sympa de dormir à la belle étoile.

Dommage d’oublier à ce point les pèlerins alors que les pèlerins en route vers Compostelle y passent et nous autres en route vers Jérusalem.

Nous nous relaxerons un peu sur les rives du beau lac de Tata (24 000 habitants quand même).

A présent, nous allons chercher un petit restaurant pour notre dîner bien mérité.

Grosse pensée également à toutes nos tatas car nous ne traverserons pas tous les jours une ville portant ce nom.

Il va falloir bien dormir cette nuit pour récupérer un maximum, car il faut bien l’admettre, nous commençons à fatiguer. Certainement que la canicule y est pour quelque chose.

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    Chemical constructions of spirostanol diglycosides isolated from Dracaena and Sansevieria
    species. Chemical structures of spirostanol monoglycosides isolated from
    Dracaena and Sansevieria species. Quite A Few informative examples of the applying of
    those strategies may be present in publications reporting saponins listed within the following tables [26,27,28,29,30,31,32,33].
    For a known saponin or sapogenin, comparability of the NMR spectra, melting level, and specific rotation with the literature is generally sufficient
    to determine the id. However, care should be used on comparing NMR spectra which have
    been decided in several solvents, as significant variations might exist.
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    used indifferently.
    It is essential to notice that in instances of glucose deprivation, most cancers cells resort to
    mitochondrial metabolic pathways somewhat than cardio glycolysis to meet their power calls for.
    The modulation of both of these metabolic pathways may be
    a more practical approach to terminating most cancers cells [83].

    Like many plant secondary metabolites, avenacins are localised within the plant vacuole.
    An interesting insight into the role of saponin glycosylation in self-protection in vegetation was made recently throughout investigation of oat mutants that fail to fully glycosylate avenacins (Mylona et al.
    2008). These mutants have stunted roots, a root hair-deficiency phenotype and membrane-trafficking defects.

    These defects had been proven to be due to accumulation of the incompletely glucosylated avenacin intermediate.

    This research critiques the impact of thermal processing on the traits and stability of saponins
    in canned bean merchandise. During soaking and blanching, portions of saponins are dissolved in water and lost in the soaking, washing, and blanching liquors.
    An optimum thermal process can enhance the steadiness and preserve the saponins
    in canned bean merchandise, which is useful for helping the meals business to enhance
    thermal processing expertise and improve bean product high quality.
    Artificial oleanolic saponins (Figure 2) have been evaluated on their antitumor [14,18,21,29,30,31,32,33,34,35,36,37], anti-Alzheimer
    [38], antiviral [39,40], antiglucosidase [41], immunomodulating [42], and
    cleansing [43] actions (Table 1).
    Calendula incorporates important quantities of oleananesaponins,
    which form two distinct collection of associated compounds, called ‘glucosides’ and ‘glucuronides’
    according to the construction of the respective precursor.

    Extracts from marigold flowers are still utilized in ointments, beauty lotions and hair‐shampoos [15].

    Some studies have advised that variations in saponin distribution and composition in crops
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    In some vegetation, for instance, Phytolacca dodecandra (gopo berry) and Dioscorea pseudojaponica (yam),
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    Efforts to improve these properties previous to 2011 have been utterly reviewed [96]; subsequently,
    our discussion was targeted on the development of lupane-type saponins after 2011 (Table 1).
    Lupane-type triterpenes have been proposed to play important roles as hydrophobic
    and antibiotic obstacles within the improvement of
    symbiosis in legumes (Hayashi et al., 2004).
    Glabra (Hayashi et al., 2004) and pea seedlings infected with Rhizobium leguminosarum (Iturbe-Ormaetxe et al., 2003).
    From an evaluation of P. sativum nodules, Hernández & Cooke (1996) detected β-amyrin in peribacteroid
    membranes and the microsomal fraction of nodule cells.
    The identification of the hallmarks of cancer is a serious milestone in understanding the
    mechanisms that drive most cancers initiation, improvement, and development.
    In the past, the hallmarks of cancer have been targeted
    to effectively treat various types of cancers.
    These typical cancer medication have shown vital therapeutic efficacy
    but proceed to impose unfavorable side effects on sufferers.

    In the years 2010–2021, a number of reviews on dammarane
    derivatives have been published, by which the SAR relationships in this group of saponins have been totally mentioned (Qi et al.
    2010; Cao et al. 2012, 2020; Nag et al. 2012). Most of the original papers that included SAR observations centered mainly on the stereoisomerism of ginsenosides
    on the positions C-20 and C-24. These information indicate
    that ginsenoside epimers differ in exercise, however this
    impact relies upon not only on the spatial configuration R or S, but in addition on the sensitivity of a specific tumor cell line (Jeong et al.
    2019; Li et al. 2019a; Nakhjavani et al. 2019).
    Macrostemonoside A [65] elevated the synthesis and release
    of visfatin in 3T3-L1 adipocytes and elevated mRNA ranges in this cytokine
    in a dose- and time-dependent mode (Zhou et al. 2007).
    In a research on C57BL/6 mice consumed a high-fat diet, this saponin when administered on the
    dose of 4 mg/kg/day for 30 days reasonably inhibited glucose degree, glycogen hepatic content material, whole
    plasma cholesterol stage and belly adipose tissue (Xie et al.
    2008).
    Sadly, just a few studies have been performed thus far on Allium steroidal glycosides.

    There are quite a few stories referring to pharmacological activities of
    steroidal saponins. Some of them showed promising antifungal, cytotoxic, anti-inflammatory, antithrombotic,
    and hypocholesterolemic results (Sparg et al. 2004; Lanzotti
    2005; Güçlü-Üstündağ and Mazza 2007). Most importantly,
    these compounds are used as substrates in the manufacturing of steroid hormones and medicines.
    The most well-known artificial lupane-type saponins are these
    derived from betulinic acid and lupeol, which are often isolated from white birch bark [91].
    Lupane-type saponins are reported to exhibit anti-inflammatory,
    antiviral and antitumor activities (Figure 4) [92,93,94].
    Nevertheless, the drug improvement of lupane-type compounds is limited
    by their low water solubility and poor pharmacokinetic profiles [95].

    Dioscin additionally downregulated L-lactic acid levels in the identical most cancers cell line, suggesting the inhibition of aberrant
    pyruvate metabolism [86]. Polyphyllin VII is a steroidal saponin isolated from Paris
    polyphylla and has been shown to induce apoptosis within the lung cancer cell line A549 through the inhibition of PI3K/Akt and NF-κB
    signaling. The downregulation of these proteins led to a lower in mitochondrial membrane potential and ultimately the induction of apoptosis.

    The PI3K inhibitor wortmannin was used in combination with
    polyphyllin VII, extenuating the compound’s inhibitory effects
    on NF-κB p65, and consequently rising the rate of apoptosis in A549 cells [53].
    The activation of the transcription factor STAT3 is noticed in many cancers contributing to their sustained proliferative
    signaling [70,71].
    Meanwhile, the mixture additionally inducedapoptosis and autophagy to promote A549/DDP cell death
    viaupregulation of p53 expression and inhibition of the cancerousinhibitor of protein phosphatase 2A/AKT/mTOR signaling
    axis(91). N45 (Fig. 2D), asteroidal saponin once often known as saponin 9
    is derived from therhizome of Paris vietnamensis (Takht.).
    Liu et al(78) confirmed that N45 exhibitedsignificant
    cytotoxic effects on glioblastoma cells
    withIC50 values of three.14 µM in U251 cells and a pair of.ninety seven µM inU87MG cells.

    The similar group proved that N45 could inducemitochondrial apoptosis
    to inhibit the proliferation oftemozolomide-resistant glioblastoma cells
    (U87R) by growing theBax/Bcl-2 ratio, and the degrees of cytochrome c and cleavedcaspase.

    The underlying molecular mechanism included the reactiveoxygen species (ROS)-mediated
    inactivation of the PI3K/AKT pathway,which resulted in downregulated expression of the nuclear factor-κB(NF-κB)
    p65 and O6-methylguanine-DNA methyltransferase (79).

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    I’m sorry to say it however his thirst for fast publicity has led him to make some outrageous and easily debunked claims which have broken his reputation endlessly.

    After 2 years spent on the soccer subject, Bradly’s need for strength training got here back.

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    Bradly Castleberry is a Pro bodybuilder, powerlifter, and
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    After college, he pursued a career in skilled soccer, however a knee injury put an finish to his dreams of playing on the highest level.

    This is fantastic for the bodybuilder’s appearance but
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    Couple this extra weight with development of the interior muscles
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    Brad is a controversial icon within the health scene, claiming to have
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  739. Steroids Vs natural pictures

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  746. Different Steroids

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    Do understand that all oral steroids will influence starvation as a end result of first cross and it might possibly trigger pressure in your cardiovascular well being or result in virilization in women. Enhances strength and muscle mass
    via improved vitality manufacturing throughout exercises.
    Stimulates development hormone release, aiding in muscle development and recovery.
    Promotes muscle progress and restoration without the
    irritant properties of certain steroids. CJC-1295 – A progress hormone-releasing peptide that enhances GH ranges for muscle growth.
    This manufacturer is famend for manufacturing
    steroids such as TREN A, Sustanon 300, and Check P
    100. Although the company’s activities have lowered significantly, it stays some of the trusted and respected steroid producers
    ever to hit the market.
    If you ran a Dbol only cycle, it might be a good suggestion to only be certain to channel your inside Gwyneth Paltrow and
    cleanse your organs. Fun reality, your liver
    can recover from most injury – your kidneys
    cannot. Whereas Dianabol is an illegal compound, D-BAL has been fomulated with pure ingredients and do not break the regulation. Most commonly utilized in its oral form, but there are oil varieties on the market.
    Let’s be honest though, the tabs are going to be easier to cover from whoever
    you’re hiding it from. Liver toxicity isn’t that dangerous, not as bad as something like Anadrol, however still
    needs to be addressed – as properly as blood pressure.
    In terms of post-cycle remedy, taking one pill of Nolvadex per day
    over three weeks following a 6-week cycle will suffice.

    Most individuals normally don’t get Omega 3 of their diet,
    and I can guarantee you the typical health club goer gets even less.

    Omega three might help with preventing inflammation, insulin resistance,
    lowering fatty liver, and reduces liver enzymes. Especially if you’re operating orals, Omega three supplementation may assist.

    Drive Manufacturing (strength) comes predominantly from
    DHT – Dihydrogentestosterone. The world is currently break up into two
    teams when it comes to « bulking Steroids ».
    One group can (and are willing) to deal with the bloat,
    Estrogen and blood pressure unwanted effects, the other group does not want all that extra junk in the trunk.

    As a outcome, it stays energetic in the physique significantly longer than natural IGF-1.
    The steroid enterprise is kind of risky, from manufacturing to consumption. A lot might go
    mistaken in any of the levels, and the consumer bears the biggest brunt.
    As such, one should do an intensive background verify
    to discover out whether the product they’re about to take is legit.
    The easiest way to get accurate details about
    a sure steroid is through the producer.
    If you want REAL steroids on the market, NEVER buy from basicstero, they don’t have real steroids.
    UGfreak.to has been round slightly more than 12
    years and is well known on some very massive steroid review web
    sites. They guarantee to deliver their packages and seem to be very assured with their approach to coping with prospects.

    Their major brand is Para pharma and their costs are very competitive.

    They are one of many sole distributors of Para Pharma, which
    is a trusted 15 years model within the trade. UGFreak is all the time on the forums and all the
    time helpful, very big assist group. When talk about USA domestic
    delivery, Domestic-supply.com (the actual one) is considered by
    most business specialists as one of the best brand to purchase domestic steroids for
    sale in the world.
    If you’re on the lookout for high quality Balkan testosterone, that is your
    go-to website. Their products aren’t solely of prime of the
    range but they’re additionally easy. The packaging is
    a high consideration as far as steroids are concerned.
    Toneupfuel is another steroid shop with top-notch support and communication.
    Turinabol is called Tbol by most gymbros and could be
    very typically missed. This handy little compound acts very
    similar to Dbol, with some slight variations. You can definitely
    use this to your advantage as it’s not going to be
    so estrogenic.
    Anadrol doesn’t convert into estrogen, therefore why the
    desk talked about that it’s not sensible to run it for too lengthy.
    It would most likely be as a end result of the reality that Anadrol acts like a progestin,
    which can have Anadrol have an effect on estrogen receptors
    directly. Unlike Anadrol, this is not illegal and will not
    impact your liver or starvation. You can get strong as all hell from these little tablets, however oh boy does it have
    unwanted anabolic side effects (Scientific-programs.science).

    Don’t get me incorrect, there aren’t any dangerous drugs, only medication getting used stupidly.

    Go straightforward, manage your sides, and reap the rewards of being the strongest bro in your health club.
    A mixture of proteins and Amino Acids along with PeakATP is bound to assist you barely in the muscle gaining endeavor.

  758. erfahrungen mit testosteron homöopathisch beim hund

    Eine Hypothese besagt, dass entsprechende mit dem Gen ausgestattete Personen zu einer besseren Nährstoffverteilung neigen. Andere wiederum, die genetisch anders ausgestattet sind, legen nicht so schnell zu.
    Und wir alle kennen diese Idee, dass ein Bekannter essen kann, wie er will, und nicht zulegt, jemand anders sieht
    einen Kuchen nur an und bekommt eine Speckrolle.
    Pima Indianer, die in Mexico leben, sind generell weit weniger fett als diejenigen ihres Stammes, die in Amerika leben. Und wie bereits vorher erwähnt, gibt es Gene, die
    die Aktivität eines Menschen beim überfüttern in die Höhe schnellen lassen. Diese Aktivität nennen wir NEAT, Non-Exercise Activity Thermogenesis.

    Trotz dieser Gene bleibt das Thema Kalorienbilanz der entscheidende Faktor.
    Studien an den Pima in Mexico haben ergeben, dass diese durchschnittlich weniger
    Kalorien aufnehmen und generell weniger gesättigte
    Fette, als ihre Stammesgenossen in Amerika. Während die genbasierte Ernährung viele Vorteile bietet, gibt
    es auch Einschränkungen, die berücksichtigt
    werden müssen. Der wohl größte Vorteil liegt in der Möglichkeit, den eigenen Körper besser
    zu verstehen und ihm genau das zu geben, was er benötigt.
    Die Personalisierung der Ernährung ermöglicht es, gezielt
    Nährstoffe zuzuführen und so die Gesundheit zu
    fördern.
    Ein weiterer Cluster, der für Forscher interessant ist,
    ist ein Cluster aus Genen, der den Fettstoffwechsel reguliert.
    Gene, die die Lipoproteine ApoA bis ApoE regulieren und beispielsweise das PPAR?

    Regulierende Gen haben besondere Varianten, die den Fettstoffwechsel maßgeblich
    beeinflussen. Diese sind hochgradig interessant für die Wahrscheinlichkeit,
    ob jemand einmal Diabetes bekommt, zu hohe Cholesterinwerte hat
    oder zu Insulinresistenz neigen könnte.
    Hochleistungssport erfordert ein angemessenes Gleichgewicht
    zwischen guter körperlicher und geistiger
    Vorbereitung, einem spezifischen Ernährungsplan, guten genetischen Voraussetzungen und einer auf diese individuellen Merkmale abgestimmten Sportplanung.
    Die Lifestyle-Genetik ist ein Bereich der Genetik, der
    den Zusammenhang zwischen Genen und individuellen Merkmalen untersucht, die sich auf einen gesunden Lebensstil auswirken. Das Ergebnis des Gentests ist nicht
    abhängig vom körperlichen oder klinischen Zustand oder vom Therapiemanagement der getesteten Particular Person. Unsere Imaginative And Prescient ist,
    dass es keine Rolle spielt, welchen Sport Sie betreiben, wie lange Sie ihn schon ausüben oder wie
    viel Erfahrung Sie erfahrungen mit testosteron homöopathisch beim hund Ihrem Training haben.
    Es spielt auch keine Rolle, ob Sie übergewichtig sind oder ob Sie Muskelmasse aufbauen wollen. Diese genetische DNA-Analyse bietet unabhängig von Ihrem sportlichen Profil die gleichen Vorteile,
    da sie auf jeden Einzelnen zugeschnitten ist.
    Zunächst sollten die Testergebnisse mit einem Experten für Ernährung oder Genetik besprochen werden. Dies stellt sicher, dass die gewonnenen Erkenntnisse
    korrekt interpretiert werden. In vielen Fällen beinhalten die
    Berichte Hinweise auf bevorzugte Nahrungsmittelgruppen, die entweder verstärkt konsumiert oder gemieden werden sollten. Ein praktisches Beispiel könnte eine Empfehlung sein, Omega-3-Fettsäuren aus Fisch oder Pflanzenölen vermehrt
    in den Speiseplan aufzunehmen, wenn der Körper
    genetisch bedingt Schwierigkeiten hat, diese selbst zu synthetisieren.
    Ich konnte durch gezieltes Coaching, basierend auf der
    genetischen Analyse, meine Zeiten verbessern. Wenn man ein olympischer Sportler werden möchte,
    dann sollte man sich seine Eltern sehr genau aussuchen.
    Spezifische Gene bestimmen die Kapazität zur Entwicklung
    von Kraft, Energy, Ausdauer, Beweglichkeit und Geschwindigkeit.
    Die Identifikation spezifischer Genvariationen bei Elitesportlern könnte
    es Wissenschaftlern eines Tages ermöglichen, das sportliche Potential junger Menschen zu bestimmen. Eine
    Variation des ACTN3 Gens wurde bei olympischen Sprintern gefunden und könnte
    einen wichtigen Vorhersagefaktor für zukünftige Erfolge darstellen. Jedes unserer DNA-Kits kann Ihnen sehr vollständige und nützliche Informationen über Ihre
    Reaktion auf körperliche Betätigung liefern, da
    sie alle die von uns analysierten Ergebnisse in Bezug auf Ihr Wohlbefinden (Abschnitt Wellness) enthalten.
    Daher ist es wichtig, einen DNA-Test für Sportler zu machen, wie wir
    ihn Ihnen mit dem tellmeGen Starter DNA-Kit anbieten. Die von 24Genetics bereitgestellten genetischen Informationen sind nur für Forschungs-, Informations- und
    Bildungszwecke gültig. In keinem Fall sind sie für den klinischen oder diagnostischen Gebrauch gültig.
    Dieser Dienst ist auf dermatologische Kliniken spezialisiert.
    Zugang und Konsultation von genetische Daten, die für Gesundheit und Pharmakologie relevant sind.

    Daher ist es wichtig, immer die Seite mit den Particulars zu beachten. Die Größe des Bewertungsbalkens
    ist proportional zur Relevanz der Auswirkung der in Ihrem Genom vorhandenen genetischen Varianten auf das
    zu bewertende Merkmal. Ein Nachteil aller Sportarten ist die Möglichkeit von Verletzungen. Aber dank Ihrer genetischen Informationen können wir
    Ihre Neigung zu bestimmten Verletzungen erkennen und
    Ihnen helfen, diese so intestine wie möglich zu vermeiden. Ein wichtiger
    Aspekt ist die bewusste Auswahl der Lebensmittel. Mithilfe der Erkenntnisse
    aus dem Gentest kannst du gezielt Produkte wählen, die deinem Körper guttun. Wenn zum Beispiel deine genetische Analyse zeigt, dass dein Körper Schwierigkeiten hat, bestimmte Vitamine
    aufzunehmen, kannst du bewusst auf Lebensmittel setzen, die diese in bioverfügbarer Form enthalten.
    Das Versprechen ist, dass man nun endlich richtig abnimmt.
    Ein großer Vorteil dieser Methode ist die Prävention von Krankheiten. Genbasierte Ernährungspläne helfen, Risikofaktoren zu identifizieren und durch gezielte Anpassungen entgegenzuwirken. Dies ist besonders related in einer Zeit, in der ernährungsbedingte Krankheiten wie Diabetes oder Herz-Kreislauf-Erkrankungen weltweit zunehmen.
    Der Traum, gesünder zu leben, ist so alt wie die Menschheit selbst.
    Was, wenn die Lösung dafür buchstäblich in unseren Genen liegt?
    Mit den Fortschritten der modernen Wissenschaft können Gentests heute wertvolle Einblicke bieten,
    um die Ernährung und den Lebensstil individuell anzupassen.
    In dem ganzen Wust der Gene, die für den deutschen Fitnessstudiogänger einfach keine Relevanz haben, gibt
    es zumindest ein paar, die auch wirklich auf eine Interaktion zwischen Essen und Genen hindeuten.
    Ein Experiment aus dem Jahr 2001 zeigt, dass einige Menschen mit erhöhter Aktivität reagieren und 69% der zugeführten überschüssigen Kalorien direkt wieder verbrennen. Andere wiederum reagieren überhaupt nicht und nehmen 100 percent
    zu. In der Wissenschaft nennt man das „Resistance to overfeeding
    induced weight gain. » Abgesehen davon ist es hochinteressant, dass der BMI vererbbar erscheint. Man schätzt, dass insgesamt 40% des BMI komplett vererbt werden. Zuerst könnte man auch denken, dass hier nur die Kultur der Eltern dran schuld ist.

    1. bglesrandonneursdu57

      Coucou Régine
      Je n’ai pas vraiment peur des araignées mais quand tu as, tout juste réveillée, une toile bien épaisse dans le visage…..
      J’ai fait un mouvement brusque de la main, mes lunettes et moi avons valsé. Du coup ma tendinite à l’épaule qui était guérie est revenue…. J’espère que ça va vite guérir.
      Pour les hébergements, ce n’est pas toujours facile. Nous avions réservé le plus possible d’hébergements à l’avance mais tu ne peux pas le faire pour plusieurs mois avant. Nous comptions sur des hébergements religieux mais à priori ils ne veulent pas vraiment de nous.
      Pour l’instant les semelles tiennent le coup mais en ce moment notre gros problème c’est la canicule alors on doit se remotiver chaque jour.
      Des gros bisous

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